InterPro in 2011: new developments in the family and domain prediction database.

TitleInterPro in 2011: new developments in the family and domain prediction database.
Publication TypeJournal Articles
Year of Publication2012
AuthorsHunter S, Jones P, Mitchell A, Apweiler R, Attwood TK, Bateman A, Bernard T, Binns D, Bork P, Burge S, de Castro E, Coggill P, Corbett M, Das U, Daugherty L, Duquenne L, Finn RD, Fraser M, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, McMenamin C, Mi H, Mutowo-Muellenet P, Mulder N, Natale D, Orengo C, Pesseat S, Punta M, Quinn AF, Rivoire C, Sangrador-Vegas A, Selengut JD, Sigrist CJA, Scheremetjew M, Tate J, Thimmajanarthanan M, Thomas PD, Wu CH, Yeats C, Yong S-Y
JournalNucleic Acids Res
Volume40
IssueDatabase issue
PaginationD306-12
Date Published2012 Jan
ISSN1362-4962
KeywordsDatabases, Protein, Protein Structure, Tertiary, Proteins, Sequence Analysis, Protein, software, Terminology as Topic, User-Computer Interface
Abstract

InterPro (http://www.ebi.ac.uk/interpro/) is a database that integrates diverse information about protein families, domains and functional sites, and makes it freely available to the public via Web-based interfaces and services. Central to the database are diagnostic models, known as signatures, against which protein sequences can be searched to determine their potential function. InterPro has utility in the large-scale analysis of whole genomes and meta-genomes, as well as in characterizing individual protein sequences. Herein we give an overview of new developments in the database and its associated software since 2009, including updates to database content, curation processes and Web and programmatic interfaces.
DOI10.1093/nar/gkr948
Alternate JournalNucleic Acids Res.
PubMed ID22096229
PubMed Central IDPMC3245097
Grant ListBB/F010508/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
GM081084 / GM / NIGMS NIH HHS / United States