Najib El-Sayed

Professor

3246 Iribe Center

(301) 405-2999

Academic Web Page

Research Group(s):

Center for Bioinformatics and Computational Biology

Education:

Ph.D., Yale University (Molecular Parasitology)

Biography:

Najib El-Sayed is a professor of cell biology and molecular genetics with an appointment in the University of Maryland Institute for Advanced Computer Studies.

His research uses genomic and bioinformatics tools to study parasitism and host-pathogen interactions, aiming to understand infection and survival mechanisms. Ultimately, he seeks to enhance the diagnosis, prevention and treatment of diseases caused by parasites and bacteria in humans, animals and plants.

Go here to view El-Sayed's academic publications on Google Scholar.

Publications

2008

Bringaud F, Ghedin E, El-Sayed NM, Papadopoulou B. 2008. Role of transposable elements in trypanosomatids. Microbes and Infection. 10(6):575-581.

Cerqueira GC, Bartholomeu DC, DaRocha WD, Hou L, Freitas-Silva DM, Machado C R, El-Sayed NM, Teixeira SMR. 2008. Sequence diversity and evolution of multigene families in Trypanosoma cruzi. Molecular and Biochemical Parasitology. 157(1):65-72.

2007

Souza RT, Santos MRM, Lima FM, El-Sayed NM, Myler PJ, Ruiz JC, da Silveira J F. 2007. New Trypanosoma cruzi Repeated Element That Shows Site Specificity for Insertion. Eukaryotic Cell. 6(7):1228-1238.

Haas BJ, Berriman M, Hirai H, Cerqueira GG, LoVerde PT, El-Sayed NM. 2007. Schistosoma mansoni genome: Closing in on a final gene set. Experimental Parasitology. 117(3):225-228.

Djikeng A, Raverdy S, Foster JS, Bartholomeu D, Zhang Y, El-Sayed NM, Carlow C. 2007. Cofactor-independent phosphoglycerate mutase is an essential gene in procyclic form Trypanosoma brucei. Parasitology research. 100(4):887-892.

Stelter K, El-Sayed NM, Seeber F. 2007. The Expression of a Plant-type Ferredoxin Redox System provides Molecular Evidence for a Plastid in the Early Dinoflagellate Perkinsus marinus. Protist. 158(1):119-130.

Waisberg M, Lobo F, Cerqueira G, Passos L, Carvalho O, Franco G, El-Sayed NM. 2007. Microarray analysis of gene expression induced by sexual contact in Schistosoma mansoni. BMC Genomics. 8(1):181-181.

2006

Bringaud F, Bartholomeu DC, Blandin G, Delcher A, Baltz T, El-Sayed NM, Ghedin E. 2006. The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion. Molecular biology and evolution. 23(2):411-411.

Westenberger S, Cerqueira G, El-Sayed NM, Zingales B, Campbell D, Sturm N. 2006. Trypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region. BMC Genomics. 7(1):60-60.

Bringaud F, Ghedin E, Blandin G, Bartholomeu DC, Caler E, Levin MJ, Baltz T, El-Sayed NM. 2006. Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements. Molecular and Biochemical Parasitology. 145(2):158-170.

Wu W, Niles EG, El-Sayed NM, Berriman M, LoVerde PT. 2006. Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors: Sixteen new members and a novel subfamily. Gene. 366(2):303-315.

2005

MacLeod A, Tweedie A, McLellan S, Taylor S, Hall N, Berriman M, El-Sayed NM, Hope M, Turner CMR, Tait A. 2005. The genetic map and comparative analysis with the physical map of Trypanosoma brucei. Nucleic acids research. 33(21):6688-6688.

El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E, Renauld H, Worthey EA, Hertz-Fowler C et al.. 2005. Comparative Genomics of Trypanosomatid Parasitic Protozoa. Science. 309(5733):404-409.

Ouhammouch M, Langham GE, Hausner W, Simpson AJ, El-Sayed NM, Geiduschek PE. 2005. Promoter architecture and response to a positive regulator of archaeal transcription. Molecular Microbiology. 56(3):625-637.

El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran A-N, Ghedin E, Worthey EA, Delcher AL, Blandin G et al.. 2005. The Genome Sequence of Trypanosoma Cruzi, Etiologic Agent of Chagas Disease. ScienceScience. 309(5733):409-415.

El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran A-N, Ghedin E, Worthey EA, Delcher AL, Blandin G et al.. 2005. The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease. Science. 309(5733):409-415.

Boonyaratanakornkit BB, Simpson AJ, Whitehead TA, Fraser CM, El-Sayed NM, Clark DS. 2005. Transcriptional profiling of the hyperthermophilic methanarchaeon Methanococcus jannaschii in response to lethal heat and non‐lethal cold shock. Environmental Microbiology. 7(6):789-797.

2004

El-Sayed NM, Bartholomeu D, Ivens A, Johnston DA, LoVerde PT. 2004. Advances in schistosome genomics. Trends in Parasitology. 20(4):154-157.

Bartholomeu D, El-Sayed NM, Melville SE. 2004. Sequencing Strategies for Parasite Genomes. METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-. 270:1-16.

Bringaud F, Biteau N, Zuiderwijk E, Berriman M, El-Sayed NM, Ghedin E, Melville SE, Hall N, Baltz T. 2004. The ingi and RIME non-LTR retrotransposons are not randomly distributed in the genome of Trypanosoma brucei. Molecular biology and evolution. 21(3):520-520.

LoVerde PT, Hirai H, Merrick JM, Lee NH, El-Sayed NM. 2004. Schistosoma mansoni genome project: an update. Parasitology International. 53(2):183-192.

2003

El-Sayed NM, Ghedin E, Song J, MacLeod A, Bringaud F, Larkin C, Wanless D, Peterson J, Hou L, Taylor S et al.. 2003. The sequence and analysis of Trypanosoma brucei chromosome II. Nucleic acids research. 31(16):4856-4856.

2002

Diehl S, Diehl F, El-Sayed NM, Clayton C, Hoheisel JD. 2002. Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray. Molecular and Biochemical Parasitology. 123(2):115-123.

Bartholomeu DC, Silva RA, Galvão LMC, El-Sayed NM, Donelson JE, Teixeira SMR. 2002. Trypanosoma cruzi: RNA structure and post-transcriptional control of tubulin gene expression. Experimental Parasitology. 102(3-4):123-133.

Bringaud F, Biteau N, Melville SE, Hez S, El-Sayed NM, Leech V, Berriman M, Hall N, Donelson JE, Baltz T. 2002. A new, expressed multigene family containing a hot spot for insertion of retroelements is associated with polymorphic subtelomeric regions of Trypanosoma brucei. Eukaryotic cell. 1(1):137-137.

Bringaud F, García-Pérez J L, Heras SR, Ghedin E, El-Sayed NM, Andersson B, Baltz T, Lopez MC. 2002. Identification of non-autonomous non-LTR retrotransposons in the genome of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 124(1-2):73-78.

2001

LaCount DJ, El-Sayed NM, Kaul S, Wanless D, Turner CMR, Donelson JE. 2001. Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes. Nucleic acids research. 29(10):2012-2012.

2000

El-Sayed NM, Hegde P, Quackenbush J, Melville SE, Donelson JE. 2000. The African trypanosome genome. International Journal for Parasitology. 30(4):329-345.

1999

Donelson JE, Gardner MJ, El-Sayed NM. 1999. More surprises from Kinetoplastida. Proceedings of the National Academy of Sciences of the United States of America. 96(6):2579-2579.

1998

Donelson JE, Hill KL, El-Sayed NM. 1998. Multiple mechanisms of immune evasion by African trypanosomes. Molecular and Biochemical Parasitology. 91(1):51-66.

1997

El-Sayed NM, Donelson JE. 1997. A survey of the Trypanosoma brucei rhodesiense genome using shotgun sequencing. Molecular and Biochemical Parasitology. 84(2):167-178.

El-Sayed NM, Donelson JE. 1997. African trypanosomes have differentially expressed genes encoding homologues of the Leishmania GP63 surface protease. Journal of Biological Chemistry. 272(42):26742-26742.

1996

Morgan RW, El-Sayed NM, Kepa JK, Pedram M, Donelson JE. 1996. Differential expression of the expression site-associated gene I family in African trypanosomes. Journal of Biological Chemistry. 271(16):9771-9771.

1995

El-Sayed NM, Patton CL, Harkins PC, Fox RO, Anderson K. 1995. Crystallization and preliminary X-ray investigation of the recombinant Trypanosoma brucei rhodesiense calmodulin. Proteins: Structure, Function, and Bioinformatics. 21(4):354-357.

El-Sayed NM, Alarcon CM, Beck JC, Sheffield VC, Donelson JE. 1995. cDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite. Molecular and Biochemical Parasitology. 73(1-2):75-90.